HEAD > PhD Muenster

Ciro Isidoro was PhD fellow (1986-1989) enrolled in the Doctor Rerum Medicinalis program (mentor Prof. Andrej Hasilik) at the Institut fuer Pathobiochemie, Westfaelish Wilhems Universitaet Muenster (Germany). Yet, he could not complete the courses till graduation (he returned to Italy due to his wife was expecting the child Alberto, who was born in March 5, 1990).

His PhD work  done in Muenster, testified by four peer-reviewed articles published ( 3 as first author) in 1990-1991 (see the list below), was not recognized by the italian institution (namely, the Department of Experimental Medicine and Oncology) because of the opposition of the then Director of the Department and of the PhD Program Prof. Mario Umberto Dianzani, in disregard of the law that allowed to award the PhD title. (soon more info on this story)

List of  the publications produced during the PhD stage in Prof. Hasilik’s laboratory in Muenster:

1: Isidoro C, Grässel S, Baccino FM, Hasilik A. Determination of the phosphorylation, uncovering of mannose 6-phosphate groups and targeting of lysosomal enzymes. Eur J Clin Chem Clin Biochem. 1991 Mar;29(3):165-71. Erratum in: Eur J Clin Chem Clin Biochem 1991 Apr;29(4):followi. PubMed PMID: 2070012.

2: Isidoro C, Horst M, Baccino FM, Hasilik A. Differential segregation of human and hamster cathepsin D in transfected baby-hamster kidney cells. Biochem J. 1991 Jan 15;273(Pt 2):363-7. PubMed PMID: 1991036; PubMed Central PMCID: PMC1149854.

3: Isidoro C, Radons J, Baccino FM, Hasilik A. Suppression of the ‘uncovering’ of mannose-6-phosphate residues in lysosomal enzymes in the presence of NH4Cl. Eur J Biochem. 1990 Aug 17;191(3):591-7. PubMed PMID: 2167847.

4: Radons J, Isidoro C, Hasilik A. Brefeldin A prevents uncovering but not phosphorylation of the recognition marker in cathepsin D. Biol Chem Hoppe Seyler. 1990 Jul;371(7):567-73. PubMed PMID: 2222855.