{"id":2667,"date":"2003-10-05T10:38:43","date_gmt":"2003-10-05T08:38:43","guid":{"rendered":"http:\/\/www.isidorolab.com\/public\/?p=2667"},"modified":"2021-09-05T11:13:27","modified_gmt":"2021-09-05T09:13:27","slug":"destination-lysosome-a-target-organelle-for-tumour-cell-killing","status":"publish","type":"post","link":"http:\/\/www.isidorolab.com\/public\/index.php\/2003\/10\/05\/destination-lysosome-a-target-organelle-for-tumour-cell-killing\/","title":{"rendered":"Destination &#8216;lysosome&#8217;: a target organelle for tumour cell killing?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2667\" class=\"elementor elementor-2667\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5545f642 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5545f642\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-46b6a8b4\" data-id=\"46b6a8b4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-17b60050 elementor-widget elementor-widget-text-editor\" data-id=\"17b60050\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Castino+R&amp;cauthor_id=14523947\">Roberta Castino<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14523947\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=D%C3%A9moz+M&amp;cauthor_id=14523947\">Marina D\u00e9moz<\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Isidoro+C&amp;cauthor_id=14523947\">Ciro Isidoro<\/a><\/p>\n<p>\u00a0<\/p>\n\n<h3 class=\"wp-block-heading\">Affiliation<\/h3>\n\n<p><sup>1<\/sup> Dipartimento di Scienze Mediche, Universit\u00e0 degli Studi del Piemonte Orientale &#8216;A Avogadro&#8217;, Novara, Italy.<\/p>\n\n<p>PMID: <strong>14523947<\/strong><\/p>\n<p>DOI: <a href=\"https:\/\/doi.org\/10.1002\/jmr.643\" target=\"_blank\" rel=\"noreferrer noopener\">10.1002\/jmr.643<\/a><\/p>\n\n<p>Review: J Mol Recognit. Sep-Oct 2003;16(5):337-48. doi: 10.1002\/jmr.643.<\/p>\n<p>\u00a0<\/p>\n<hr \/>\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n<p>Lysosomes and lysosome-related organelles constitute a system of acid compartments that interconnect the inside of the cell with the extracellular environment via endocytosis, phagocytosis and exocytosis. In recent decades it has been recognized that lysosomes are not just wastebaskets for disposal of unused cellular constituents, but that they are involved in several cellular processes such as post-translational maturation of proteins, degradation of receptors and extracellular release of active enzymes. By complementing the autophagic process, lysosomes actively contribute to the maintenance of cellular homeostasis. Proteolysis by lysosomal cathepsins has been shown to mediate the death signal of cytotoxic drugs and cytokines, as well as the activation of pro-survival factors. Secreted lysosomal cathepsins have been shown to degrade protein components of the extracellular matrix, thus contributing actively to its re-modelling in physiological and pathological processes. The malfunction of lysosomes can, therefore, impact on cell behaviour and fate. Here we review the role of lysosomal hydrolases in several aspects of the malignant phenotype including loss of cell growth control, altered regulation of cell death, acquisition of chemoresistance and of metastatic potential. Based on these observations, the lysosome is proposed as a potential target organelle for the chemotherapy of tumours. We will also present some recent data concerning the technologies for delivering chemotherapeutic drugs to the endosomal-lysosomal compartment and the strategies to improve their efficacy.<\/p>\n<p>\u00a0<\/p>\n\n<p id=\"copyright\">Copyright 2003 John Wiley &amp; Sons, Ltd.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t<div style='text-align:center' class='yasr-auto-insert-visitor'><!--Yasr Visitor Votes Shortcode--><div id='yasr_visitor_votes_32ea68509f47f' class='yasr-visitor-votes'><div class=\"yasr-custom-text-vv-before yasr-custom-text-vv-before-2667\">Clicca per votare questo articolo!<\/div><div id='yasr-vv-second-row-container-32ea68509f47f'\r\n                                        class='yasr-vv-second-row-container'><div id='yasr-visitor-votes-rater-32ea68509f47f'\r\n                                      class='yasr-rater-stars-vv'\r\n                                      data-rater-postid='2667'\r\n                                      data-rating='0'\r\n                                      data-rater-starsize='32'\r\n                                      data-rater-readonly='false'\r\n                                      data-rater-nonce='e156304cd3'\r\n                                      data-issingular='false'\r\n                                    ><\/div><div class=\"yasr-vv-stats-text-container\" id=\"yasr-vv-stats-text-container-32ea68509f47f\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\"\r\n                                   class=\"yasr-dashicons-visitor-stats\"\r\n                                   data-postid=\"2667\"\r\n                                   id=\"yasr-stats-dashicon-32ea68509f47f\">\r\n                                   <path d=\"M18 18v-16h-4v16h4zM12 18v-11h-4v11h4zM6 18v-8h-4v8h4z\"><\/path>\r\n                               <\/svg><span id=\"yasr-vv-text-container-32ea68509f47f\" class=\"yasr-vv-text-container\">[Total: <span id=\"yasr-vv-votes-number-container-32ea68509f47f\">0<\/span>  Average: <span id=\"yasr-vv-average-container-32ea68509f47f\">0<\/span>]<\/span><\/div><div id='yasr-vv-loader-32ea68509f47f' class='yasr-vv-container-loader'><\/div><\/div><div id='yasr-vv-bottom-container-32ea68509f47f' class='yasr-vv-bottom-container'><\/div><\/div><!--End Yasr Visitor Votes Shortcode--><\/div>","protected":false},"excerpt":{"rendered":"<p>Roberta Castino\u00a0 1 ,\u00a0Marina D\u00e9moz,\u00a0Ciro Isidoro \u00a0 Affiliation 1 Dipartimento di Scienze Mediche, Universit\u00e0 degli Studi del Piemonte Orientale &#8216;A Avogadro&#8217;, Novara, Italy. PMID: 14523947 DOI: 10.1002\/jmr.643 Review: J Mol Recognit. Sep-Oct 2003;16(5):337-48. doi: 10.1002\/jmr.643. \u00a0 Abstract Lysosomes and lysosome-related organelles constitute a system of acid compartments that interconnect the inside of the cell with&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"yasr_overall_rating":0,"yasr_post_is_review":"","yasr_auto_insert_disabled":"","yasr_review_type":"","footnotes":""},"categories":[136],"tags":[55],"class_list":["post-2667","post","type-post","status-publish","format-standard","hentry","category-paper","tag-cancer"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Destination &#039;lysosome&#039;: a target organelle for tumour cell killing? - IsidoroLab<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"http:\/\/www.isidorolab.com\/public\/index.php\/2003\/10\/05\/destination-lysosome-a-target-organelle-for-tumour-cell-killing\/\" \/>\r\n<meta property=\"og:locale\" content=\"it_IT\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Destination &#039;lysosome&#039;: a target organelle for tumour cell killing? - IsidoroLab\" \/>\r\n<meta property=\"og:description\" content=\"Roberta Castino\u00a0 1 ,\u00a0Marina D\u00e9moz,\u00a0Ciro Isidoro \u00a0 Affiliation 1 Dipartimento di Scienze Mediche, Universit\u00e0 degli Studi del Piemonte Orientale &#8216;A Avogadro&#8217;, Novara, Italy. 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