{"id":2704,"date":"2021-06-21T12:15:08","date_gmt":"2021-06-21T10:15:08","guid":{"rendered":"http:\/\/www.isidorolab.com\/public\/?p=2704"},"modified":"2021-09-05T12:16:35","modified_gmt":"2021-09-05T10:16:35","slug":"cyclodextrin-nanosponge-for-the-gsh-mediated-delivery-of-resveratrol-in-human-cancer-cells","status":"publish","type":"post","link":"http:\/\/www.isidorolab.com\/public\/index.php\/2021\/06\/21\/cyclodextrin-nanosponge-for-the-gsh-mediated-delivery-of-resveratrol-in-human-cancer-cells\/","title":{"rendered":"Cyclodextrin nanosponge for the GSH-mediated delivery of Resveratrol in human cancer cells"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2704\" class=\"elementor elementor-2704\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-76f1d247 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"76f1d247\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1c00c678\" data-id=\"1c00c678\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54b86b76 elementor-widget elementor-widget-text-editor\" data-id=\"54b86b76\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Palminteri+M&amp;cauthor_id=33564618\">Marco Palminteri<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33564618\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Dhakar+NK&amp;cauthor_id=33564618\">Nilesh Kumar Dhakar<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33564618\/#affiliation-2\"> 2 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ferraresi+A&amp;cauthor_id=33564618\">Alessandra Ferraresi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33564618\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Caldera+F&amp;cauthor_id=33564618\">Fabrizio Caldera<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33564618\/#affiliation-2\"> 2 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Vidoni+C&amp;cauthor_id=33564618\">Chiara Vidoni<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33564618\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Trotta+F&amp;cauthor_id=33564618\">Francesco Trotta<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33564618\/#affiliation-2\"> 2 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Isidoro+C&amp;cauthor_id=33564618\">Ciro Isidoro<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33564618\/#affiliation-1\"> 1<\/a><\/sup><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n\n<h3 class=\"wp-block-heading\">Affiliations<\/h3>\n\n<p><sup>1<\/sup> Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Novara, Italy.<\/p>\n<p><sup>2<\/sup> Department of Chemistry, University of Turin, via P. Giuria 7, 10125, Turin, Italy.<\/p>\n<p>\u00a0<\/p>\n\n<p>PMID: <strong>33564618<\/strong><\/p>\n<p>PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7868003\/\" target=\"_blank\" rel=\"noreferrer noopener\">PMC7868003<\/a><\/p>\n<p>DOI: <a href=\"https:\/\/doi.org\/10.7150\/ntno.53888\" target=\"_blank\" rel=\"noreferrer noopener\">10.7150\/ntno.53888<\/a><\/p>\n\n<p>Nanotheranostics. 2021 Jan 21;5(2):197-212. doi: 10.7150\/ntno.53888. eCollection 2021.<\/p>\n<p>\u00a0<\/p>\n<hr \/>\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n<p>Smart drug delivery systems are required for the site-specific drug targeting to enhance the therapeutic efficiency of a drug. Resveratrol (RV) is a polyphenolic compound with anti-cancer activity. However, its poor aqueous solubility and non-selectivity are the major challenges for its employment in cancer therapy. In this work, we present the synthesis of RV-loaded glutathione responsive cyclodextrin nanosponges (RV-GSH-NSs) to improve the therapeutic efficiency and selective delivery of RV. The drug loading and encapsulation efficiency were 16.12% and 80.64%, respectively. The <em>in vitro<\/em> release profile confirmed that RV release was enhanced in response to external glutathione (GSH). Nude NSs were not toxic <em>per se<\/em> to human fibroblasts when administered for up to 72 h at the highest dose. Cell internalization studies confirmed that RV-GSH-NSs were preferentially up-taken by tumor cells compared to non-tumorigenic cells. Accordingly, RV showed selective toxicity to cancer cells compared to normal cells. GSH depletion by buthionine sulfoximine, a potent inhibitor of its synthesis, reflected in a significant decrease of the NSs accumulation, and consequently resulted in a drastic reduction of RV-mediated toxic effects in cancer cells. These findings demonstrate that GSH- responsive NSs represent an effective delivery system for targeting cancer cells by harnessing the differential tumor characteristics in terms of redox status in parallel with the limitation of side effects toward normal cells.<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n\n<p><strong>Keywords:<\/strong> Resveratrol; breast cancer; glutathione; ovarian cancer; \u03b2-cyclodextrin nanosponge.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t<div style='text-align:center' class='yasr-auto-insert-visitor'><!--Yasr Visitor Votes Shortcode--><div id='yasr_visitor_votes_8d029d176d5b9' class='yasr-visitor-votes'><div class=\"yasr-custom-text-vv-before yasr-custom-text-vv-before-2704\">Clicca per votare questo articolo!<\/div><div id='yasr-vv-second-row-container-8d029d176d5b9'\r\n                                        class='yasr-vv-second-row-container'><div id='yasr-visitor-votes-rater-8d029d176d5b9'\r\n                                      class='yasr-rater-stars-vv'\r\n                                      data-rater-postid='2704'\r\n                                      data-rating='0'\r\n                                      data-rater-starsize='32'\r\n                                      data-rater-readonly='false'\r\n                                      data-rater-nonce='bb8f69d06e'\r\n                                      data-issingular='false'\r\n                                    ><\/div><div class=\"yasr-vv-stats-text-container\" id=\"yasr-vv-stats-text-container-8d029d176d5b9\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\"\r\n                                   class=\"yasr-dashicons-visitor-stats\"\r\n                                   data-postid=\"2704\"\r\n                                   id=\"yasr-stats-dashicon-8d029d176d5b9\">\r\n                                   <path d=\"M18 18v-16h-4v16h4zM12 18v-11h-4v11h4zM6 18v-8h-4v8h4z\"><\/path>\r\n                               <\/svg><span id=\"yasr-vv-text-container-8d029d176d5b9\" class=\"yasr-vv-text-container\">[Total: <span id=\"yasr-vv-votes-number-container-8d029d176d5b9\">0<\/span>  Average: <span id=\"yasr-vv-average-container-8d029d176d5b9\">0<\/span>]<\/span><\/div><div id='yasr-vv-loader-8d029d176d5b9' class='yasr-vv-container-loader'><\/div><\/div><div id='yasr-vv-bottom-container-8d029d176d5b9' class='yasr-vv-bottom-container'><\/div><\/div><!--End Yasr Visitor Votes Shortcode--><\/div>","protected":false},"excerpt":{"rendered":"<p>Marco Palminteri\u00a0 1 ,\u00a0Nilesh Kumar Dhakar\u00a0 2 ,\u00a0Alessandra Ferraresi\u00a0 1 ,\u00a0Fabrizio Caldera\u00a0 2 ,\u00a0Chiara Vidoni\u00a0 1 ,\u00a0Francesco Trotta\u00a0 2 ,\u00a0Ciro Isidoro\u00a0 1 \u00a0 \u00a0 Affiliations 1 Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Novara, Italy. 2 Department of Chemistry, University of Turin, via P. Giuria 7, 10125, Turin,&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"yasr_overall_rating":0,"yasr_post_is_review":"","yasr_auto_insert_disabled":"","yasr_review_type":"","footnotes":""},"categories":[136],"tags":[55],"class_list":["post-2704","post","type-post","status-publish","format-standard","hentry","category-paper","tag-cancer"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Cyclodextrin nanosponge for the GSH-mediated delivery of Resveratrol in human cancer cells - IsidoroLab<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"http:\/\/www.isidorolab.com\/public\/index.php\/2021\/06\/21\/cyclodextrin-nanosponge-for-the-gsh-mediated-delivery-of-resveratrol-in-human-cancer-cells\/\" \/>\r\n<meta property=\"og:locale\" content=\"it_IT\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Cyclodextrin nanosponge for the GSH-mediated delivery of Resveratrol in human cancer cells - IsidoroLab\" \/>\r\n<meta property=\"og:description\" content=\"Marco Palminteri\u00a0 1 ,\u00a0Nilesh Kumar Dhakar\u00a0 2 ,\u00a0Alessandra Ferraresi\u00a0 1 ,\u00a0Fabrizio Caldera\u00a0 2 ,\u00a0Chiara Vidoni\u00a0 1 ,\u00a0Francesco Trotta\u00a0 2 ,\u00a0Ciro Isidoro\u00a0 1 \u00a0 \u00a0 Affiliations 1 Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Novara, Italy. 2 Department of Chemistry, University of Turin, via P. Giuria 7, 10125, Turin,&hellip;\" \/>\r\n<meta property=\"og:url\" content=\"http:\/\/www.isidorolab.com\/public\/index.php\/2021\/06\/21\/cyclodextrin-nanosponge-for-the-gsh-mediated-delivery-of-resveratrol-in-human-cancer-cells\/\" \/>\r\n<meta property=\"og:site_name\" content=\"IsidoroLab\" \/>\r\n<meta property=\"article:published_time\" content=\"2021-06-21T10:15:08+00:00\" \/>\r\n<meta property=\"article:modified_time\" content=\"2021-09-05T10:16:35+00:00\" \/>\r\n<meta name=\"author\" content=\"ciro_isidoro\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"ciro_isidoro\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2021\/06\/21\/cyclodextrin-nanosponge-for-the-gsh-mediated-delivery-of-resveratrol-in-human-cancer-cells\/#article\",\"isPartOf\":{\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2021\/06\/21\/cyclodextrin-nanosponge-for-the-gsh-mediated-delivery-of-resveratrol-in-human-cancer-cells\/\"},\"author\":{\"name\":\"ciro_isidoro\",\"@id\":\"https:\/\/www.isidorolab.com\/public\/#\/schema\/person\/09655d5679e249988585d483f7fccb44\"},\"headline\":\"Cyclodextrin nanosponge for the GSH-mediated delivery of Resveratrol in human cancer cells\",\"datePublished\":\"2021-06-21T10:15:08+00:00\",\"dateModified\":\"2021-09-05T10:16:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2021\/06\/21\/cyclodextrin-nanosponge-for-the-gsh-mediated-delivery-of-resveratrol-in-human-cancer-cells\/\"},\"wordCount\":291,\"keywords\":[\"cancer\"],\"articleSection\":[\"Paper\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2021\/06\/21\/cyclodextrin-nanosponge-for-the-gsh-mediated-delivery-of-resveratrol-in-human-cancer-cells\/\",\"url\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2021\/06\/21\/cyclodextrin-nanosponge-for-the-gsh-mediated-delivery-of-resveratrol-in-human-cancer-cells\/\",\"name\":\"Cyclodextrin nanosponge for the GSH-mediated delivery of Resveratrol in human cancer cells - 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