{"id":2743,"date":"2020-11-23T12:49:35","date_gmt":"2020-11-23T11:49:35","guid":{"rendered":"http:\/\/www.isidorolab.com\/public\/?p=2743"},"modified":"2021-09-05T12:51:01","modified_gmt":"2021-09-05T10:51:01","slug":"epigenetic-targeting-of-autophagy-for-cancer-prevention-and-treatment-by-natural-compounds","status":"publish","type":"post","link":"http:\/\/www.isidorolab.com\/public\/index.php\/2020\/11\/23\/epigenetic-targeting-of-autophagy-for-cancer-prevention-and-treatment-by-natural-compounds\/","title":{"rendered":"Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2743\" class=\"elementor elementor-2743\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-25d3f1df elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"25d3f1df\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7a68298d\" data-id=\"7a68298d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2ea4312e elementor-widget elementor-widget-text-editor\" data-id=\"2ea4312e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Vidoni+C&amp;cauthor_id=31054926\">Chiara Vidoni<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31054926\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ferraresi+A&amp;cauthor_id=31054926\">Alessandra Ferraresi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31054926\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Secomandi+E&amp;cauthor_id=31054926\">Eleonora Secomandi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31054926\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Vallino+L&amp;cauthor_id=31054926\">Letizia Vallino<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31054926\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Dhanasekaran+DN&amp;cauthor_id=31054926\">Danny N Dhanasekaran<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31054926\/#affiliation-2\"> 2 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Isidoro+C&amp;cauthor_id=31054926\">Ciro Isidoro<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31054926\/#affiliation-3\"> 3<\/a><\/sup><\/p>\n<p>\u00a0<\/p>\n\n<h3 class=\"wp-block-heading\">Affiliations<\/h3>\n\n<p><sup>1<\/sup> Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Via Solaroli 17, 28100, Novara, Italy.<\/p>\n<p><sup>2<\/sup> Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.<\/p>\n<p><sup>3<\/sup> Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Via Solaroli 17, 28100, Novara, Italy. Electronic address: ciro.isidoro@med.uniupo.it<\/p>\n<p>\u00a0<\/p>\n\n<p>PMID: <strong>31054926<\/strong><\/p>\n<p>DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.semcancer.2019.04.006\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.semcancer.2019.04.006<\/a><\/p>\n\n<p>Review: Semin Cancer Biol. 2020 Nov;66:34-44. doi: 10.1016\/j.semcancer.2019.04.006. Epub 2019 May 2.<\/p>\n<p>\u00a0<\/p>\n<hr \/>\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n<p>Despite the undeniable progress made in the last decades, cancer continues to challenge the scientists engaged in searching for an effective treatment for its prevention and cure. One of the malignant hallmarks that characterize cancer cell biology is the altered metabolism of sugars and amino acids. Autophagy is a pathway allowing the macromolecular turnover via recycling of the substrates resulting from the lysosomal degradation of damaged or redundant cell molecules and organelles. As such, autophagy guarantees the proteome quality control and cell homeostasis. Data from in vitro, in animals and in patients researches show that dysregulation of autophagy favors carcinogenesis and cancer progression, making this process an ineluctable target of cancer therapy. The autophagy process is regulated at genetic, epigenetic and post-translational levels. Targeting autophagy with epigenetic modifiers could represent a valuable strategy to prevent or treat cancer. A wealth of natural products from terrestrial and marine living organisms possess anti-cancer activity. Here, we review the experimental proofs demonstrating the ability of natural compounds to regulate autophagy in cancer via epigenetics. The hope is that in the near future this knowledge could translate into effective intervention to prevent and cure cancer.<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n\n<p><strong>Keywords:<\/strong> Cell metabolism; Herb; Long non coding RNA; Therapy; miRNA.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t<div style='text-align:center' class='yasr-auto-insert-visitor'><!--Yasr Visitor Votes Shortcode--><div id='yasr_visitor_votes_6f435644daf9f' class='yasr-visitor-votes'><div class=\"yasr-custom-text-vv-before yasr-custom-text-vv-before-2743\">Clicca per votare questo articolo!<\/div><div id='yasr-vv-second-row-container-6f435644daf9f'\r\n                                        class='yasr-vv-second-row-container'><div id='yasr-visitor-votes-rater-6f435644daf9f'\r\n                                      class='yasr-rater-stars-vv'\r\n                                      data-rater-postid='2743'\r\n                                      data-rating='0'\r\n                                      data-rater-starsize='32'\r\n                                      data-rater-readonly='false'\r\n                                      data-rater-nonce='51aff3753d'\r\n                                      data-issingular='false'\r\n                                    ><\/div><div class=\"yasr-vv-stats-text-container\" id=\"yasr-vv-stats-text-container-6f435644daf9f\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\"\r\n                                   class=\"yasr-dashicons-visitor-stats\"\r\n                                   data-postid=\"2743\"\r\n                                   id=\"yasr-stats-dashicon-6f435644daf9f\">\r\n                                   <path d=\"M18 18v-16h-4v16h4zM12 18v-11h-4v11h4zM6 18v-8h-4v8h4z\"><\/path>\r\n                               <\/svg><span id=\"yasr-vv-text-container-6f435644daf9f\" class=\"yasr-vv-text-container\">[Total: <span id=\"yasr-vv-votes-number-container-6f435644daf9f\">0<\/span>  Average: <span id=\"yasr-vv-average-container-6f435644daf9f\">0<\/span>]<\/span><\/div><div id='yasr-vv-loader-6f435644daf9f' class='yasr-vv-container-loader'><\/div><\/div><div id='yasr-vv-bottom-container-6f435644daf9f' class='yasr-vv-bottom-container'><\/div><\/div><!--End Yasr Visitor Votes Shortcode--><\/div>","protected":false},"excerpt":{"rendered":"<p>Chiara Vidoni\u00a0 1 ,\u00a0Alessandra Ferraresi\u00a0 1 ,\u00a0Eleonora Secomandi\u00a0 1 ,\u00a0Letizia Vallino\u00a0 1 ,\u00a0Danny N Dhanasekaran\u00a0 2 ,\u00a0Ciro Isidoro\u00a0 3 \u00a0 Affiliations 1 Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Via Solaroli 17, 28100, Novara, Italy. 2 Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City,&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"yasr_overall_rating":0,"yasr_post_is_review":"","yasr_auto_insert_disabled":"","yasr_review_type":"","footnotes":""},"categories":[136],"tags":[44],"class_list":["post-2743","post","type-post","status-publish","format-standard","hentry","category-paper","tag-autophagy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds - IsidoroLab<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"http:\/\/www.isidorolab.com\/public\/index.php\/2020\/11\/23\/epigenetic-targeting-of-autophagy-for-cancer-prevention-and-treatment-by-natural-compounds\/\" \/>\r\n<meta property=\"og:locale\" content=\"it_IT\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds - IsidoroLab\" \/>\r\n<meta property=\"og:description\" content=\"Chiara Vidoni\u00a0 1 ,\u00a0Alessandra Ferraresi\u00a0 1 ,\u00a0Eleonora Secomandi\u00a0 1 ,\u00a0Letizia Vallino\u00a0 1 ,\u00a0Danny N Dhanasekaran\u00a0 2 ,\u00a0Ciro Isidoro\u00a0 3 \u00a0 Affiliations 1 Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. 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