{"id":3044,"date":"2022-05-16T13:09:46","date_gmt":"2022-05-16T11:09:46","guid":{"rendered":"http:\/\/www.isidorolab.com\/public\/?p=3044"},"modified":"2022-05-16T13:15:46","modified_gmt":"2022-05-16T11:15:46","slug":"resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i","status":"publish","type":"post","link":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/","title":{"rendered":"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3044\" class=\"elementor elementor-3044\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5b38c1b2 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5b38c1b2\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6a8b49c3\" data-id=\"6a8b49c3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f37662b elementor-widget elementor-widget-text-editor\" data-id=\"f37662b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<header id=\"heading\" class=\"heading\"><div id=\"full-view-heading\" class=\"full-view\"><div class=\"inline-authors\"><div class=\"authors\"><div class=\"authors-list\"><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Esposito+A&amp;cauthor_id=35565270\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Andrea Esposito\">Andrea Esposito<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &quot;A. Avogadro&quot;, Via Solaroli 17, 28100 Novara, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35565270\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Ferraresi+A&amp;cauthor_id=35565270\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Alessandra Ferraresi\">Alessandra Ferraresi<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &quot;A. Avogadro&quot;, Via Solaroli 17, 28100 Novara, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35565270\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Salwa+A&amp;cauthor_id=35565270\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Amreen Salwa\">Amreen Salwa<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &quot;A. Avogadro&quot;, Via Solaroli 17, 28100 Novara, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35565270\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Vidoni+C&amp;cauthor_id=35565270\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Chiara Vidoni\">Chiara Vidoni<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &quot;A. Avogadro&quot;, Via Solaroli 17, 28100 Novara, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35565270\/#affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Dhanasekaran+DN&amp;cauthor_id=35565270\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Danny N Dhanasekaran\">Danny N Dhanasekaran<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35565270\/#affiliation-2\">2<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Isidoro+C&amp;cauthor_id=35565270\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Ciro Isidoro\">Ciro Isidoro<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &quot;A. Avogadro&quot;, Via Solaroli 17, 28100 Novara, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35565270\/#affiliation-1\">1<\/a><\/sup><\/span><\/div><\/div><\/div><div class=\"short-article-details\"><button id=\"toggle-authors\" class=\"more-details\" data-alt-text=\"Collapse\" aria-controls=\"expanded-authors\" aria-expanded=\"false\" data-pinger-ignore=\"\" data-fetch-url=\"\/35565270\/long-authors\/\" data-id-prefix=\"\">Affiliations<\/button><ul class=\"item-list\"><li data-affiliation-id=\"affiliation-1\"><sup class=\"key\">1<\/sup>Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Via Solaroli 17, 28100 Novara, Italy.<\/li><li data-affiliation-id=\"affiliation-2\"><sup class=\"key\">2<\/sup>Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.<\/li><\/ul><\/div><ul id=\"full-view-identifiers\" class=\"identifiers\"><li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID: <\/span><strong class=\"current-id\" title=\"PubMed ID\">35565270<\/strong><\/span><\/li>\u00a0<li><span class=\"identifier pmc\"><span class=\"id-label\">PMCID:\u00a0<\/span><a class=\"id-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc9101105\/\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"PMCID\">PMC9101105<\/a><\/span><\/li>\u00a0<li><span class=\"identifier doi\"><span class=\"id-label\">DOI:\u00a0<\/span><a class=\"id-link\" href=\"https:\/\/doi.org\/10.3390\/cancers14092142\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\">10.3390\/cancers14092142<\/a><\/span><\/li><\/ul><span class=\"free-label\">Free PMC article<\/span><\/div><\/header><div id=\"abstract\" class=\"abstract\"><h2 class=\"title\">Abstract<\/h2><div id=\"enc-abstract\" class=\"abstract-content selected\"><p>Tumor dormancy is the extended period during which patients are asymptomatic before recurrence, and it represents a difficult phenomenon to target pharmacologically. The relapse of tumors, for instance arising from the interruption of dormant metastases, is frequently observed in ovarian cancer patients and determines poor survival. Inflammatory cytokines present in the tumor microenvironment likely contribute to such events. Cancer cell dormancy and autophagy are interconnected at the molecular level through ARH-I (DIRAS3) and BECLIN-1, two tumor suppressors often dysregulated in ovarian cancers. IL-6 disrupts autophagy in ovarian cancer cells via miRNAs downregulation of ARH-I, an effect contrasted by the nutraceutical protein restriction mimetic resveratrol (RV). By using three ovarian cancer cell lines with different genetic background in 2D and 3D models, the latter mimicking the growth of peritoneal metastases, we show that RV keeps the cancer cells in a dormant-like quiescent state contrasting the IL-6 growth-promoting activity. Mechanistically, this effect is mediated by BECLIN-1-dependent autophagy and relies on the availability of ARH-I. We also show that\u00a0<i>ARH-I<\/i>\u00a0(<i>DIRAS3<\/i>) is a\u00a0<i>bona fide<\/i>\u00a0target of miR-1305, a novel oncomiRNA upregulated by IL-6 and downregulated by RV. Clinically relevant, bioinformatic analysis of a transcriptomic database showed that the high expression of\u00a0<i>DIRAS3<\/i>\u00a0and\u00a0<i>MAP1LC3B<\/i>\u00a0mRNAs together with that of\u00a0<i>CDKN1A<\/i>, directing a cellular dormant phenotype, predicts better overall survival in ovarian cancer patients, and this correlates with\u00a0<i>MIR1305<\/i>\u00a0downregulation. The possibility of maintaining a permanent cell dormancy in ovarian cancer by the chronic administration of RV should be considered as a therapeutic option to prevent the &#8220;awakening&#8221; of cancer cells in response to a permissive microenvironment, thus limiting the risk of tumor relapse and metastasis.<\/p><\/div><p><strong class=\"sub-title\">Keywords:\u00a0<\/strong>3D spheroids; ARH-I; DIRAS3; autophagy; epigenetics; interleukin-6; microRNA; ovarian cancer; tumor microenvironment.<\/p><p>\u00a0<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t<div style='text-align:center' class='yasr-auto-insert-visitor'><!--Yasr Visitor Votes Shortcode--><div id='yasr_visitor_votes_d502626089815' class='yasr-visitor-votes'><div class=\"yasr-custom-text-vv-before yasr-custom-text-vv-before-3044\">Clicca per votare questo articolo!<\/div><div id='yasr-vv-second-row-container-d502626089815'\r\n                                        class='yasr-vv-second-row-container'><div id='yasr-visitor-votes-rater-d502626089815'\r\n                                      class='yasr-rater-stars-vv'\r\n                                      data-rater-postid='3044'\r\n                                      data-rating='0'\r\n                                      data-rater-starsize='32'\r\n                                      data-rater-readonly='false'\r\n                                      data-rater-nonce='bb8f69d06e'\r\n                                      data-issingular='false'\r\n                                    ><\/div><div class=\"yasr-vv-stats-text-container\" id=\"yasr-vv-stats-text-container-d502626089815\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\"\r\n                                   class=\"yasr-dashicons-visitor-stats\"\r\n                                   data-postid=\"3044\"\r\n                                   id=\"yasr-stats-dashicon-d502626089815\">\r\n                                   <path d=\"M18 18v-16h-4v16h4zM12 18v-11h-4v11h4zM6 18v-8h-4v8h4z\"><\/path>\r\n                               <\/svg><span id=\"yasr-vv-text-container-d502626089815\" class=\"yasr-vv-text-container\">[Total: <span id=\"yasr-vv-votes-number-container-d502626089815\">0<\/span>  Average: <span id=\"yasr-vv-average-container-d502626089815\">0<\/span>]<\/span><\/div><div id='yasr-vv-loader-d502626089815' class='yasr-vv-container-loader'><\/div><\/div><div id='yasr-vv-bottom-container-d502626089815' class='yasr-vv-bottom-container'><\/div><\/div><!--End Yasr Visitor Votes Shortcode--><\/div>","protected":false},"excerpt":{"rendered":"<p>Andrea Esposito\u00a01,\u00a0Alessandra Ferraresi\u00a01,\u00a0Amreen Salwa\u00a01,\u00a0Chiara Vidoni\u00a01,\u00a0Danny N Dhanasekaran\u00a02,\u00a0Ciro Isidoro\u00a01Affiliations 1Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Via Solaroli 17, 28100 Novara, Italy. 2Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. PMID: 35565270 \u00a0 PMCID:\u00a0PMC9101105 \u00a0 DOI:\u00a010.3390\/cancers14092142 Free PMC article Abstract Tumor dormancy&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"yasr_overall_rating":0,"yasr_post_is_review":"","yasr_auto_insert_disabled":"","yasr_review_type":"","footnotes":""},"categories":[136],"tags":[55],"class_list":["post-3044","post","type-post","status-publish","format-standard","hentry","category-paper","tag-cancer"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I - IsidoroLab<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/\" \/>\r\n<meta property=\"og:locale\" content=\"it_IT\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I - IsidoroLab\" \/>\r\n<meta property=\"og:description\" content=\"Andrea Esposito\u00a01,\u00a0Alessandra Ferraresi\u00a01,\u00a0Amreen Salwa\u00a01,\u00a0Chiara Vidoni\u00a01,\u00a0Danny N Dhanasekaran\u00a02,\u00a0Ciro Isidoro\u00a01Affiliations 1Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Via Solaroli 17, 28100 Novara, Italy. 2Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. PMID: 35565270 \u00a0 PMCID:\u00a0PMC9101105 \u00a0 DOI:\u00a010.3390\/cancers14092142 Free PMC article Abstract Tumor dormancy&hellip;\" \/>\r\n<meta property=\"og:url\" content=\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/\" \/>\r\n<meta property=\"og:site_name\" content=\"IsidoroLab\" \/>\r\n<meta property=\"article:published_time\" content=\"2022-05-16T11:09:46+00:00\" \/>\r\n<meta property=\"article:modified_time\" content=\"2022-05-16T11:15:46+00:00\" \/>\r\n<meta name=\"author\" content=\"ciro_isidoro\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"ciro_isidoro\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/#article\",\"isPartOf\":{\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/\"},\"author\":{\"name\":\"ciro_isidoro\",\"@id\":\"https:\/\/www.isidorolab.com\/public\/#\/schema\/person\/09655d5679e249988585d483f7fccb44\"},\"headline\":\"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I\",\"datePublished\":\"2022-05-16T11:09:46+00:00\",\"dateModified\":\"2022-05-16T11:15:46+00:00\",\"mainEntityOfPage\":{\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/\"},\"wordCount\":368,\"keywords\":[\"cancer\"],\"articleSection\":[\"Paper\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/\",\"url\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/\",\"name\":\"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I - IsidoroLab\",\"isPartOf\":{\"@id\":\"https:\/\/www.isidorolab.com\/public\/#website\"},\"datePublished\":\"2022-05-16T11:09:46+00:00\",\"dateModified\":\"2022-05-16T11:15:46+00:00\",\"author\":{\"@id\":\"https:\/\/www.isidorolab.com\/public\/#\/schema\/person\/09655d5679e249988585d483f7fccb44\"},\"breadcrumb\":{\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.isidorolab.com\/public\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.isidorolab.com\/public\/#website\",\"url\":\"https:\/\/www.isidorolab.com\/public\/\",\"name\":\"IsidoroLab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.isidorolab.com\/public\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.isidorolab.com\/public\/#\/schema\/person\/09655d5679e249988585d483f7fccb44\",\"name\":\"ciro_isidoro\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/www.isidorolab.com\/public\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/bb38c41275320421f71f7cbd289a8451?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/bb38c41275320421f71f7cbd289a8451?s=96&d=mm&r=g\",\"caption\":\"ciro_isidoro\"},\"url\":\"http:\/\/www.isidorolab.com\/public\/index.php\/author\/ciro_isidoro\/\"},false]}<\/script>\r\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I - IsidoroLab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/","og_locale":"it_IT","og_type":"article","og_title":"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I - IsidoroLab","og_description":"Andrea Esposito\u00a01,\u00a0Alessandra Ferraresi\u00a01,\u00a0Amreen Salwa\u00a01,\u00a0Chiara Vidoni\u00a01,\u00a0Danny N Dhanasekaran\u00a02,\u00a0Ciro Isidoro\u00a01Affiliations 1Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Via Solaroli 17, 28100 Novara, Italy. 2Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. PMID: 35565270 \u00a0 PMCID:\u00a0PMC9101105 \u00a0 DOI:\u00a010.3390\/cancers14092142 Free PMC article Abstract Tumor dormancy&hellip;","og_url":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/","og_site_name":"IsidoroLab","article_published_time":"2022-05-16T11:09:46+00:00","article_modified_time":"2022-05-16T11:15:46+00:00","author":"ciro_isidoro","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"ciro_isidoro","Tempo di lettura stimato":"2 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/#article","isPartOf":{"@id":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/"},"author":{"name":"ciro_isidoro","@id":"https:\/\/www.isidorolab.com\/public\/#\/schema\/person\/09655d5679e249988585d483f7fccb44"},"headline":"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I","datePublished":"2022-05-16T11:09:46+00:00","dateModified":"2022-05-16T11:15:46+00:00","mainEntityOfPage":{"@id":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/"},"wordCount":368,"keywords":["cancer"],"articleSection":["Paper"],"inLanguage":"it-IT"},{"@type":"WebPage","@id":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/","url":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/","name":"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I - IsidoroLab","isPartOf":{"@id":"https:\/\/www.isidorolab.com\/public\/#website"},"datePublished":"2022-05-16T11:09:46+00:00","dateModified":"2022-05-16T11:15:46+00:00","author":{"@id":"https:\/\/www.isidorolab.com\/public\/#\/schema\/person\/09655d5679e249988585d483f7fccb44"},"breadcrumb":{"@id":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/www.isidorolab.com\/public\/index.php\/2022\/05\/16\/resveratrol-contrasts-il-6-pro-growth-effects-and-promotes-autophagy-mediated-cancer-cell-dormancy-in-3d-ovarian-cancer-role-of-mir-1305-and-of-its-target-arh-i\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.isidorolab.com\/public\/"},{"@type":"ListItem","position":2,"name":"Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I"}]},{"@type":"WebSite","@id":"https:\/\/www.isidorolab.com\/public\/#website","url":"https:\/\/www.isidorolab.com\/public\/","name":"IsidoroLab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.isidorolab.com\/public\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"},{"@type":"Person","@id":"https:\/\/www.isidorolab.com\/public\/#\/schema\/person\/09655d5679e249988585d483f7fccb44","name":"ciro_isidoro","image":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/www.isidorolab.com\/public\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/bb38c41275320421f71f7cbd289a8451?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/bb38c41275320421f71f7cbd289a8451?s=96&d=mm&r=g","caption":"ciro_isidoro"},"url":"http:\/\/www.isidorolab.com\/public\/index.php\/author\/ciro_isidoro\/"},false]}},"yasr_visitor_votes":{"stars_attributes":{"read_only":false,"span_bottom":false},"number_of_votes":0,"sum_votes":0},"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/posts\/3044","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/comments?post=3044"}],"version-history":[{"count":7,"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/posts\/3044\/revisions"}],"predecessor-version":[{"id":3052,"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/posts\/3044\/revisions\/3052"}],"wp:attachment":[{"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/media?parent=3044"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/categories?post=3044"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.isidorolab.com\/public\/index.php\/wp-json\/wp\/v2\/tags?post=3044"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}