{"id":2725,"date":"2020-07-23T12:34:16","date_gmt":"2020-07-23T10:34:16","guid":{"rendered":"http:\/\/www.isidorolab.com\/public\/?p=2725"},"modified":"2021-09-05T12:36:18","modified_gmt":"2021-09-05T10:36:18","slug":"ovarian-mitochondrial-dynamics-and-cell-fate-regulation-in-an-androgen-induced-rat-model-of-polycystic-ovarian-syndrome","status":"publish","type":"post","link":"https:\/\/www.isidorolab.com\/public\/index.php\/2020\/07\/23\/ovarian-mitochondrial-dynamics-and-cell-fate-regulation-in-an-androgen-induced-rat-model-of-polycystic-ovarian-syndrome\/","title":{"rendered":"Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2725\" class=\"elementor elementor-2725\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-21cb5f79 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"21cb5f79\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3d6edbf7\" data-id=\"3d6edbf7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4ce50a7f elementor-widget elementor-widget-text-editor\" data-id=\"4ce50a7f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Salehi+R&amp;cauthor_id=31974436\">Reza Salehi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Mazier+HL&amp;cauthor_id=31974436\">Hannah L Mazier<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-1\"> 1 <\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-2\"> 2 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Nivet+AL&amp;cauthor_id=31974436\">Anne-Laure Nivet<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-1\"> 1 <\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-2\"> 2 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Reunov+AA&amp;cauthor_id=31974436\">Arkadiy A Reunov<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-3\"> 3 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lima+P&amp;cauthor_id=31974436\">Patricia Lima<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Wang+Q&amp;cauthor_id=31974436\">Qi Wang<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-1\"> 1 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Fiocco+A&amp;cauthor_id=31974436\">Arianna Fiocco<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-2\"> 2 <\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-4\"> 4 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Isidoro+C&amp;cauthor_id=31974436\">Ciro Isidoro<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-5\"> 5 <\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Tsang+BK&amp;cauthor_id=31974436\">Benjamin K Tsang<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-6\"> 6 <\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31974436\/#affiliation-7\"> 7<\/a><\/sup><\/p>\n<p>\u00a0<\/p>\n\n<h3 class=\"wp-block-heading\">Affiliations<\/h3>\n\n<p><sup>1<\/sup> Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada.<\/p>\n<p><sup>2<\/sup> Department of Cellular &amp; Molecular Medicine and Obstetrics &amp; Gynecology, University of Ottawa, Ottawa, Canada.<\/p>\n<p><sup>3<\/sup> Electron Microscopy Laboratory, University of Ottawa Heart Institute, Ottawa, Canada.<\/p>\n<p><sup>4<\/sup> Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Via P. Solaroli 17, 28100, Novara, Italy.<\/p>\n<p><sup>5<\/sup> Laboratory of Molecular Pathology, Department of Health Sciences, Universit\u00e0 del Piemonte Orientale &#8220;A. Avogadro&#8221;, Via P. Solaroli 17, 28100, Novara, Italy. ciro.isidoro@med.uniupo.it.<\/p>\n<p><sup>6<\/sup> Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada. btsang@ohri.ca.<\/p>\n<p><sup>7<\/sup> Department of Cellular &amp; Molecular Medicine and Obstetrics &amp; Gynecology, University of Ottawa, Ottawa, Canada. btsang@ohri.ca.<\/p>\n<p>\u00a0<\/p>\n\n<p>PMID: <strong>31974436<\/strong><\/p>\n<p>PMCID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc6978404\/\" target=\"_blank\" rel=\"noreferrer noopener\">PMC6978404<\/a><\/p>\n<p>DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41598-020-57672-w\" target=\"_blank\" rel=\"noreferrer noopener\">10.1038\/s41598-020-57672-w<\/a><\/p>\n\n<p>Sci Rep. 2020 Jan 23;10(1):1021. doi: 10.1038\/s41598-020-57672-w.<\/p>\n<p>\u00a0<\/p>\n<hr \/>\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n<p>In this study, we investigated in an androgenized rat model the involvement of autophagy and mitochondrial dynamics in granulosa cells in the pathogenesis of polycystic ovarian syndrome (PCOS) and its modulation by exogenous gonadotropin (eCG). We found 5\u03b1-dihydrotestosterone (DHT) treatment reduces ovarian length and weight with predominantly late antral and\/or preovulatory stage follicles and no corpora lutea. DHT increased the population of large lysosomes (&gt;50 micron) and macroautophagy, an event associated with granulosa cell apoptosis. Increased granulosa cell Dynamin Related Protein 1 (Drp1) content in the DHT group was accompanied by increased circular and constricted, but reduced rod-shaped, mitochondria. eCG eliminated all atypical follicles and increased the number of late antral and preovulatory follicles with less granulosa cell apoptosis. eCG-treated rats had a higher proportion of connected mitochondria, and in combination with DHT had a lower proportion of circular and constricted mitochondria than rats treated with DHT alone, suggesting that eCG induces mitochondrial fusion and attenuates fission in granulosa cells. In summary, we observed that DHT-induced up-regulation of Drp1 is associated with excessive mitochondrial fission, macroautophagy and apoptosis in granulosa cells at the antral stage of development in an androgenized rat model for PCOS, a response partially attenuated by exogenous gonadotropin.<\/p>\n\n<p>\u00a0<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t<div style='text-align:center' class='yasr-auto-insert-visitor'><!--Yasr Visitor Votes Shortcode--><div id='yasr_visitor_votes_d96c6510c412d' class='yasr-visitor-votes'><div class=\"yasr-custom-text-vv-before yasr-custom-text-vv-before-2725\">Clicca per votare questo articolo!<\/div><div id='yasr-vv-second-row-container-d96c6510c412d'\r\n                                        class='yasr-vv-second-row-container'><div id='yasr-visitor-votes-rater-d96c6510c412d'\r\n                                      class='yasr-rater-stars-vv'\r\n                                      data-rater-postid='2725'\r\n                                      data-rating='0'\r\n                                      data-rater-starsize='32'\r\n                                      data-rater-readonly='false'\r\n                                      data-rater-nonce='c951f25266'\r\n                                      data-issingular='false'\r\n                                    ><\/div><div class=\"yasr-vv-stats-text-container\" id=\"yasr-vv-stats-text-container-d96c6510c412d\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\"\r\n                                   class=\"yasr-dashicons-visitor-stats\"\r\n                                   data-postid=\"2725\"\r\n                                   id=\"yasr-stats-dashicon-d96c6510c412d\">\r\n                                   <path d=\"M18 18v-16h-4v16h4zM12 18v-11h-4v11h4zM6 18v-8h-4v8h4z\"><\/path>\r\n                               <\/svg><span id=\"yasr-vv-text-container-d96c6510c412d\" class=\"yasr-vv-text-container\">[Total: <span id=\"yasr-vv-votes-number-container-d96c6510c412d\">0<\/span>  Average: <span id=\"yasr-vv-average-container-d96c6510c412d\">0<\/span>]<\/span><\/div><div id='yasr-vv-loader-d96c6510c412d' class='yasr-vv-container-loader'><\/div><\/div><div id='yasr-vv-bottom-container-d96c6510c412d' class='yasr-vv-bottom-container'><\/div><\/div><!--End Yasr Visitor Votes Shortcode--><\/div>","protected":false},"excerpt":{"rendered":"<p>Reza Salehi\u00a0 1 ,\u00a0Hannah L Mazier\u00a0 1 \u00a0 2 ,\u00a0Anne-Laure Nivet\u00a0 1 \u00a0 2 ,\u00a0Arkadiy A Reunov\u00a0 3 ,\u00a0Patricia Lima\u00a0 1 ,\u00a0Qi Wang\u00a0 1 ,\u00a0Arianna Fiocco\u00a0 2 \u00a0 4 ,\u00a0Ciro Isidoro\u00a0 5 ,\u00a0Benjamin K Tsang\u00a0 6 \u00a0 7 \u00a0 Affiliations 1 Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada. 2 Department of Cellular &amp;&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"yasr_overall_rating":0,"yasr_post_is_review":"","yasr_auto_insert_disabled":"","yasr_review_type":"","footnotes":""},"categories":[136],"tags":[55],"class_list":["post-2725","post","type-post","status-publish","format-standard","hentry","category-paper","tag-cancer"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - 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