Closing the loop: A dynamic “sample-to-answer” Ecosystem for vascularized tumor modeling and real-time therapies

Ciro Isidoro ¹, Yong Sang Song ², Danny N Dhanasekaran ³

• PMID: 41687769
• DOI: 10.1016/j.canlet.2026.218302

Introduction

Advances in patient-derived organoid technologies have significantly improved our ability to model tumor-specific biology and therapeutic response in vitro. However, most current platforms remain limited by incomplete representation of the tumor microenvironment and reliance on static, endpoint-based analytical workflows [1]. Addressing these limitations is essential for improving the translational relevance of organoid-based cancer models. In this context, the study by Ruan et al. introduces an integrated microfluidic platform that enables continuous vascularized tumor modeling coupled with real-time biomarker monitoring [2].