Autore: ciro_isidoro

Ciro Isidoro 1, Yong Sang Song 2, Danny N Dhanasekaran 3 Introduction Advances in patient-derived organoid technologies have significantly improved our ability to model tumor-specific biology and therapeutic response in vitro. However, most current platforms remain limited by incomplete representation of the tumor microenvironment and reliance on static, endpoint-based analytical workflows [1]. Addressing these limitations is essential for improving the…

Camelia Munteanu 1, Revathy Nadhan 2, Sabina Turti 1, Eftimia Prifti 1, Larisa Achim 1, Sneha Basu 2 3, Alessandra Ferraresi 4, Ji Hee Ha 2, Ciro Isidoro 4, Danny N Dhanasekaran 1 3 5 Abstract Cancer remains a leading cause of morbidity and mortality worldwide, and effective strategies for cancer prevention are urgently needed to complement therapeutic advances. While dietary factors are known to influence cancer risk, the molecular mechanisms that mediate inter-individual responses to nutritional…

Revathy Nadhan 1, Karthik Nath 2, Sneha Basu 1 3, Ciro Isidoro 4, Yong Sang Song 5, Danny N Dhanasekaran 6 7 8 Abstract Lysophosphatidic acid (LPA) signaling has emerged as a central regulatory axis in both normal physiology and disease, orchestrating diverse cellular processes such as proliferation, survival, migration, immune modulation, and tissue remodeling. Originally identified as a bioactive lipid that regulates smooth muscle contraction and vascular tone,…

Gentilissime e gentilissimi,condivido con voi la versione in italiano (gentilmente tradotta da Arianna Vocaturo Ciampolillo) del mio articolo “SARS-CoV2 e vaccini anti-COVID-19 a mRNA: esiste un plausibile legame meccanicistico con il cancro?” pubblicato sulla rivista scientifica internazionale peer-review Cancers il 4 dicembre 2025 e che potete scaricare a questo LINK. In questo lavoro ho approfondito…

Simple Summary Between 2021 and 2024, large segments of the population—including cancer patients— experienced multiple COVID-19 infections and received repeated doses of mRNA vaccines. The concomitant increase in newly diagnosed cancers or fast progression of cancers under treatment raised concerns about whether SARS-CoV-2 or the vaccines might play a role in these outcomes. While it…

Valentina Bonetto  1 , Alessandra Ferraresi  2 , Simonetta Sampò  3 , Ciro Isidoro  2 Affiliations Abstract Aging is a complex biological process characterized by progressive multiorgan deterioration that compromises the quality of life. Unhealthy aging often associates with cognitive decline and motor-neurological disorders including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Genetic, environmental, and lifestyle factors, which…