Autore: ciro_isidoro

Curative effect of xanthohumol supplementation during liver fluke-associated cholangiocarcinogenesis: Potential involvement of autophagy

di ciro_isidoro

Suyanee Thongchot  1   2   3 , Malinee Thanee  1   3 , Watcharin Loilome  1   3 , Anchalee Techasen  3   4 , Thidarat Boonmars  3   5 , Prakasit Sa-Ngiamwibool  3   6 , Attapol Titapun  3   7 , Puangrat Yongvanit  3 , Ciro Isidoro  2 , Nisana Namwat  1   3   Affiliations 1 Department of Biochemistry, Faculty…

Preconditioning-induced cytoprotection in hepatocytes requires Ca(2+)-dependent exocytosis of lysosomes

di ciro_isidoro

Rita Carini  1, Roberta Castino, Maria Grazia De Cesaris, Roberta Splendore, Marina Démoz, Emanuele Albano, Ciro Isidoro   Affiliation 1 Laboratory of Pathology, Dipartimento di Scienze Mediche, Università del Piemonte Orientale A. Avogadro, via Solaroli 17, 28100 Novara, Italy. PMID: 14970255 DOI: 10.1242/jcs.00923 J Cell Sci. 2004 Mar 1;117(Pt 7):1065-77. doi: 10.1242/jcs.00923. Epub 2004 Feb 17.   Abstract A short period…

Destination ‘lysosome’: a target organelle for tumour cell killing?

di ciro_isidoro

Roberta Castino  1 , Marina Démoz, Ciro Isidoro   Affiliation 1 Dipartimento di Scienze Mediche, Università degli Studi del Piemonte Orientale ‘A Avogadro’, Novara, Italy. PMID: 14523947 DOI: 10.1002/jmr.643 Review: J Mol Recognit. Sep-Oct 2003;16(5):337-48. doi: 10.1002/jmr.643.   Abstract Lysosomes and lysosome-related organelles constitute a system of acid compartments that interconnect the inside of the cell with…

Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D

di ciro_isidoro

Marina Démoz  1 , Roberta Castino, Patrizia Cesaro, Francesco M Baccino, Gabriella Bonelli, Ciro Isidoro   Affiliation 1 Dipartimento di Scienze Mediche, Università A Avogadro, Novara, Italy. PMID: 12437111 DOI: 10.1515/BC.2002.137 Biol Chem. Jul-Aug 2002;383(7-8):1237-48. doi: 10.1515/BC.2002.137.   Abstract In several ‘in vitro’ models of apoptosis, lysosomal proteolysis has been shown to play an active role in mediating the death…

Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells

di ciro_isidoro

Daniela De Stefanis  1 , Patrizia Reffo, Gabriella Bonelli, Francesco M Baccino, Giuseppina Sala, Riccardo Ghidoni, Patrice Codogno, Ciro Isidoro   Affiliation 1 Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy. PMID: 12222689 DOI: 10.1515/BC.2002.106   Abstract Ceramide has been suggested as an important mediator of apoptosis. In HT-29 colorectal cancer cells increased ceramide levels, induced by exogenous N-acetylsphingosine (NAS,…

Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas

di ciro_isidoro

Roberta Castino  1 , Deborah Pace, Marina Démoz, Marco Gargiulo, Chiara Ariatta, Elisabetta Raiteri, Ciro Isidoro Affiliation 1 Dipartimento di Scienze Mediche, Laboratorio di Patologia Molecolare, Università A. Avogadro, Novara, Italy.   PMID: 11857353 DOI: 10.1002/ijc.10139   Abstract Neuroblastoma is the most common type of cancer in infants. In children this tumor is particularly aggressive; despite various new therapeutic approaches, it…

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